Vasotec side effect cough7/26/2023 ![]() Demographic and Clinical Characteristics of Patients Presenting With Angiotensin-converting Enzyme Inhibitors Induced Cough. Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines. Do You Have a Cough that Won’t Go Away? Available at. Angiotensin-Converting Enzyme Inhibitors Induce Cough. For that reason, ACE inhibitors are also prescribed to treat and prevent heart failure. It also decreases harmful changes that can happen to the heart, known as cardiac remodeling. ![]() Hypertrophy, or thickening, of the walls of blood vessels and heart tissue, which contributes to heart failure.īlocking ACE leads to lower blood pressure.Increased sodium in the body leads to increased blood pressure. The release of aldosterone, a hormone that causes sodium to be reabsorbed.The constriction of blood vessels, which increases blood pressure and makes the heart work harder.Angiotensin II has several effects on the cardiovascular system. Angiotensin-converting enzyme (ACE) converts a hormone known as angiotensin I to angiotensin II. How ACE inhibitors workĪCE inhibitors lower blood pressure by blocking angiotensin-converting enzyme. Never stop taking any medicine on your own. There may be other medicines you can take instead. If you’re bothered by a cough while taking an ACE inhibitor, talk with your health care provider. Blocking ACE (by taking an ACE inhibitor) allows bradykinin and substance P to build up in the lungs, which can lead to coughing. Bradykinin and substance P cause tightening of the smooth muscle in the lungs, which leads to coughing. One way ACE inhibitors may cause a cough is through the actions of two compounds: bradykinin and substance P. The cough usually goes away within 1 to 4 weeks after stopping an ACE inhibitor, but it can take up to 3 months.Ĭough may be more likely to develop in women, and according to an observational study published in 2019 in the journal Cureus, people who are over 65 years of age and those taking cholesterol-lowering drugs may also be more likely to experience cough. It may start after the first dose, or it may take weeks or months. The cough can start any time during treatment with an ACE inhibitor. Available medications in this class include:ĪCE inhibitors can cause a dry, tickly cough in 4% to 35% of people who take them. Angiotensin-converting enzyme (ACE) inhibitors are a class of prescription blood pressure medications that commonly cause coughing as a side effect.
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